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KMID : 0361020020450121152
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Korean Journal of Otolaryngology - Head and Neck Surgery
2002 Volume.45 No. 12 p.1152 ~ p.1156
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The Expression of Bcl-xL and Bax in Nasal Polyps
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황성재/Sung Jae Hwang
윤희로/조진희/방충일/강준명/박재우/강민곤/He Ro Yoon/Jin Hee Cho/Choong Ill Bang/Jun Myung Kang/Jae Woo Park/Min Gon Kang
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Abstract
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Background and Objectives: The etiology and the pathophysiology of nasal polyps are still not definitely known and recently, it is suggested that inflammatory responses involving eosinophils may play a major role. The process of the
infiltration
of eosinophils in tissues is explained by the increase of the movement of eosinophils to the inflammatory area and the delay of apoptosis which results in the longer survival of eosinophils. Recently, there have been studies showing how
eosinophils
extracted from blood expressed their anti-apoptotic Bcl-xL genes and pro-apoptotic Bax genes when put in a delayed apoptotic condition. The purpose of this study is to investigate Bcl-xL and Bax expressions of eosinophils in
nasal
polyps and how allergic rhinitis affect their expression. Materials and Method: Nasal polyps were obtained from patients with chronic paranasal sinusitis (30 cases) and nasal polyps were divided into two groups, ons obtained from the patient
with
allergic rhinitis (15 cases) and the other obtained from the patient without allergic rhinitis (15 case). The normal control group consisted of 5 cases of normal nasal mucosa in the inferior turbinate. The immunohistochemical stain was used to
detect
eosinophils and the cells expressing Bcl-xL and Bax. Results: In nasl polyps, a significant statistical correlation between eosinophil numbers and Bcl-xL positive cell numbers was detected. But there was no
correlation
between them in the normal control. The Bax positive cell numbers has a correlation to eosinophils numbers in both the normal control and nasal polyps. And allergic rhinitis did not affect the expression of Bcl-xL and Bax of eosinophils
in
nasal polyps. Conclusion: The authors propose that in eosinophils of nasal polyps. Bcl-xL plays an important role in delayed apoptosis and allergic rhinitis has no effect on the expression of Bcl-xL and Bax.
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